Synthesis of 4-hydroxy-3-methylchalcone from Reimer-Tiemann reaction product and its antibacterial activity test
| Autor: | Tri Windarti, Ismiyarto, M Hapsari, Ngadiwiyana, Purbowatiningrum |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chalcone biology Vanillin 030106 microbiology Reimer–Tiemann reaction medicine.disease_cause biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences chemistry.chemical_compound chemistry Staphylococcus aureus Melting point medicine Organic chemistry Antibacterial activity Bacteria Acetophenone |
| Zdroj: | IOP Conference Series: Materials Science and Engineering. 349:012036 |
| ISSN: | 1757-899X 1757-8981 |
| DOI: | 10.1088/1757-899x/349/1/012036 |
| Popis: | A 4-hydroxy-3-methylchalcone has been synthesized from 4-hydroxy-3-methylbenzaldehyde as the Reimer-Tiemann reaction product. This research consists of three steps involve synthesize of 4-hydroxy-3-methylbenzaldehyde from ortho-cresol, synthesize of chalcone derivatives from 4-hydroxy-3-methylbenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde or vanillin for the comparison, the last is antibacterial activity test of both chalcone derivatives against Escherichia coli (negative gram) and Staphylococcus aureus (positive gram) bacteria using disc diffusion method. Results of Reimer-Tiemann reaction is 4-hydroxy-3-methylbenzaldehyde compound in an orange colour solid form which has 43% yields and melting point 110-114°C. A 4-hydroxy-3-methylbenzaldehyde then reacted with acetophenone in a base condition and form 4-hydroxy-3-methylchalcone compound in a yellow colour solid form which has 40% yields and melting point 83-86°C. The antibacterial activity of the 4-hydroxy-3-methylchalcone against gram-positive bacteria Staphylococcus aureus is better than the 4-hydroxy-3-methoxychalcone. |
| Databáze: | OpenAIRE |
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