Hemocompatibility and cytocompatibility of pristine and plasma-treated silver-zeolite-chitosan composites
| Autor: | Kathrina Lois M. Taaca, Magdaleno R. Vasquez |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
General Physics and Astronomy 02 engineering and technology Surfaces and Interfaces General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Casting Surface energy 0104 chemical sciences Surfaces Coatings and Films Chitosan Solvent Matrix (chemical analysis) chemistry.chemical_compound chemistry Wetting Composite material 0210 nano-technology Zeolite Antibacterial activity |
| Zdroj: | Applied Surface Science. 432:324-331 |
| ISSN: | 0169-4332 |
| DOI: | 10.1016/j.apsusc.2017.04.034 |
| Popis: | Silver-exchanged zeolite-chitosan (AgZ-Ch) composites with varying AgZ content were prepared by solvent casting and modified under argon (Ar) plasma excited by a 13.56 MHz radio frequency (RF) power source. Silver (Ag) was successfully incorporated in a natural zeolite host without losing its antibacterial activity against Escherichia coli and Staphylococcus aureus . The AgZ particles were incorporated into a chitosan matrix without making significant changes in the matrix structure. The composites also exhibited antibacterial sensitivity due to the inclusion of AgZ. Plasma treatment enhanced the surface wettability of polar and nonpolar test liquids of the composites. The average increase in total surface free energy after treatment was around 49% with the polar component having a significant change. Cytocompatibility tests showed at least 87% cell viability for pristine and plasma-treated composites comparable with supplemented RPMI as positive control. Hemocompatibility tests revealed that pristine composites does not promote hemolysis and the blood clotting ability is less than 10 min. Coupled with antibacterial property, the fabricated composites have promising biomedical applications. |
| Databáze: | OpenAIRE |
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