Terpenoids from the Fermented Broths of Coprinellus radians
Autor: | Ruo Kai Lin, Ming Shian Lee, Yueh-Hsiung Kuo, Tzong-Huei Lee, Yu-Ming Ju, Che Jen Hsiao |
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Rok vydání: | 2016 |
Předmět: |
Pharmacology
Cryptococcus neoformans Coprinellus radians Chromatography biology 010405 organic chemistry Chemistry Ethyl acetate Plant Science General Medicine 010402 general chemistry biology.organism_classification 01 natural sciences Terpenoid Corpus albicans 0104 chemical sciences Microbiology chemistry.chemical_compound Complementary and alternative medicine Amphotericin B Drug Discovery medicine Fermentation Candida albicans medicine.drug |
Zdroj: | Natural Product Communications. 11:1934578X1601100 |
ISSN: | 1555-9475 1934-578X |
Popis: | One new sesquiterpenoid, namely coprinol (1), along with guanacastanes J (2), E (3) and N (4), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Coprinellus radians#1168. Their structures were elucidated on the basis of spectroscopic data analysis. The growth inhibitory activities against A549 of 1-4 were evaluated, and only 4 exhibited moderate growth inhibitory activity with a GI50 value of 18.2 μM compared with fluorouracil (GI50 = 3.6 μM). All the compounds were also subjected to antifungal assay against Candida albicans ATCC 18804, C. albicans SC-5314, Cryptococcus neoformans ATCC 13690 and Saccharomyces cerevisiae ATCC 2345; all showed mild antifungal activity with MIC values of 128.0 μg/mL for 1-3 and 64.0 μg/mL for 4 in comparison with amphotericin B (MIC = 0.25 μg/mL) and ketoconazole (MIC = 1.0 μg/mL). |
Databáze: | OpenAIRE |
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