Age of Appearance of Diabetes Autoantibodies in Type 1a Diabetics and Their Siblings in Côte D'ivoire
| Autor: | Sanogo Mamadou, Djaman Allico Joseph, Lokrou Adrian, Ankotche Amos, Trebissou Aisse Florence Judith, Yapo Adou Francis, Sibailly Pascal, Hatem Masmoudi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
endocrine system
Embryology Type 1 diabetes Indirect immunofluorescence endocrine system diseases business.industry Mortality rate Autoantibody nutritional and metabolic diseases Physiology Cote d ivoire Cell Biology medicine.disease Young age Diabetes mellitus medicine Population study Anatomy business Developmental Biology |
| Zdroj: | Advances in Diabetes and Metabolism. 6:16-23 |
| ISSN: | 2332-0060 2332-0052 |
| DOI: | 10.13189/adm.2018.060202 |
| Popis: | Diabetes autoantibodies, which are important markers of classification and prevention of type 1 diabetes, are absent in the diabetes care in Cote d'Ivoire. The study aim was to determine the age at which these autoantibodies were at their highest levels in type 1A diabetic patients (T1D) and their siblings in Cote d’Ivoire. The study population is composed of 28 T1D patients and 59 siblings, aged from 5 to 21 years. T1D were followed up in the U.H.C Endocrinology departments of Yopougon and Treichville, in the District of Abidjan. Anti-GAD and anti-IA2 autoantibodies were researched by ELISA and anti-ICA autoantibodies by indirect immunofluorescence on monkey pancreas. The peaks of anti-GAD and anti-IA2 autoantibodies were observed respectively at 9 years old (604.30±521.70 IU/ml) and 10 years old (125.10±90.10 IU/ml) in T1D. In siblings, the peaks of anti-GAD and anti-IA2 autoantibodies were observed respectively at 13 years old (137 IU/ml) and 10 years old (53±40 IU/ml). The peak of diabetes autoantibodies in T1D and their siblings in Cote d'Ivoire is at a very young age noted. This could explain the high mortality rate among T1D youth in Cote d'Ivoire. |
| Databáze: | OpenAIRE |
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