An assessment of dexmedetomidine as an opioid-sparing agent after neonatal open thoracic and abdominal operations

Autor: Parisa Oviedo, Alicia G Sykes, Alexandra S. Rooney, Gerald Gollin
Rok vydání: 2021
Předmět:
Zdroj: Journal of Perinatology. 42:307-312
ISSN: 1476-5543
0743-8346
DOI: 10.1038/s41372-021-01175-7
Popis: Objective To evaluate the efficacy of dexmedetomidine as an opioid-sparing agent in infants following open thoracic or abdominal operations. Methods Retrospective review of postoperative neonates who received IV acetaminophen with or without dexmedetomidine. The primary outcome was opioid dosage within the first ten postoperative days. Secondary outcomes included times to extubation, full feedings and discharge. Results 112 infants met inclusion criteria. Those managed with dexmedetomidine received 1.8-4.3 times more opioid on postoperative days 1-3, had longer times to extubation and trended towards longer lengths of hospital stay than infants who were not. Opioid was dosed >0.2 ME/kg on only 23% of days when the acetaminophen dose was >40 mg/kg/day and 10% of days when the acetaminophen dose was >45 mg/kg. Conclusion Dexmedetomidine may not be opioid sparing after major operations in neonates and its use delays recovery. IV acetaminophen dosed at 40 mg/kg/day or greater may yield the most substantial opioid-sparing effect.
Databáze: OpenAIRE
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