| Autor: |
J A Tibble, T Mahmud, Ingvar Bjarnason, G Sigthorsson |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Inflammopharmacology. 8:31-41 |
| ISSN: |
0925-4692 |
| DOI: |
10.1023/b:infl.0000041130.58342.15 |
| Popis: |
There is irrefutable evidence that cyclooxygenase-1 (COX-1) inhibition by itself is not the only factor in the development of the gastrointestinal damage of NSAIDs. One suggestion is that the 'topical' effect of NSAIDs is an important initiating factor in their toxicity ('ion trapping hypothesis'), but the biochemical mechanisms are unknown. We made an integrated approach to elucidate the biochemical basis of the 'topical' toxicity of NSAIDs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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