Synthesis and biological activity of pyrimido [1, 2-a] quinoline moiety and its 2-substituted derivatives

Autor:	A G Jadhav, N K Halikar
Rok vydání:	2013
Předmět:	History Quinoline Medicinal chemistry Computer Science Applications Education Potassium carbonate chemistry.chemical_compound Aniline chemistry Organic chemistry Moiety Amine gas treating Methylene Methyl group Malononitrile
Zdroj:	Journal of Physics: Conference Series. 423:012007
ISSN:	1742-6596 1742-6588
DOI:	10.1088/1742-6596/423/1/012007
Popis:	2-Amino-3-cyano quinoline (1) and bis (methylthio) methylene malononitrile (2) were refluxed in N,N-dimethyl formamide (DMF) in presence of catalytic amount of anhydrous potassium carbonate to afforded 3, 11-dicyano-4-imino-2-methylthio -4H-pyrimido [1, 2-a] quinoline (3). The latter were further reacted with different substituted aniline, phenol, hetryl amine and compound containing active methyl group. Afforded to 3, 11-dicyano-4-imino -4H-pyrimido [1, 2-a] quinoline and their 2-substuited derivatives (4a-7c). All these newly synthesized compounds were characterized by elemental analysis and spectral data, and screened for their antimicrobial activities.
Databáze:	OpenAIRE
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