Remodeling- and Modeling-Based Bone Formation With Teriparatide Versus Denosumab: A Longitudinal Analysis From Baseline to 3 Months in the AVA Study
| Autor: | Sudhaker D Rao, Robert R. Recker, Valerie A Ruff, Jahangir Alam, Kathleen A. Taylor, David L. Kendler, Hua Zhou, Christopher Recknor, Jacques P. Brown, John H. Krege, Robert Lindsay, David W Dempster, Thomas E. Melby, Paul D. Miller, E. Michael Lewiecki |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Periosteum medicine.medical_specialty Postmenopausal women medicine.diagnostic_test Anabolism business.industry Endocrinology Diabetes and Metabolism Osteoporosis Urology 030209 endocrinology & metabolism medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Denosumab Biopsy medicine Teriparatide Orthopedics and Sports Medicine Bone formation business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Journal of Bone and Mineral Research. 33:298-306 |
| ISSN: | 0884-0431 |
| Popis: | There has been renewed interest of late in the role of modeling-based formation (MBF) during osteoporosis therapy. Here we describe early effects of an established anabolic (teriparatide) versus antiresorptive (denosumab) agent on remodeling-based formation (RBF), MBF, and overflow MBF (oMBF) in human transiliac bone biopsies. Postmenopausal women with osteoporosis received subcutaneous teriparatide (n = 33, 20 μg/d) or denosumab (n = 36, 60 mg once/6 months), open-label for 6 months at 7 US and Canadian sites. Subjects received double fluorochrome labeling at baseline and before biopsy at 3 months. Sites of bone formation were designated as MBF if the underlying cement line was smooth, RBF if scalloped, and oMBF if formed over smooth cement lines adjacent to scalloped reversal lines. At baseline, mean RBF/bone surface (BS), MBF/BS, and oMBF/BS were similar between the teriparatide and denosumab groups in each bone envelope assessed (cancellous, endocortical, periosteal). All types of formation significantly increased from baseline in the cancellous and endocortical envelopes (differences p |
| Databáze: | OpenAIRE |
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