CARCINO-EMBRYONIC ANTIGEN (CEA) IN GASTRIC ADENOCARCINOMAS
| Autor: | P S Teglbjaerg, Karsten Nielsen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty endocrine system diseases General Immunology and Microbiology Immunoperoxidase Cell General Medicine Biology Histogenesis Mucus digestive system diseases Glycocalyx medicine.anatomical_structure Immunology and Microbiology (miscellaneous) Antigen Cytoplasm medicine Apical cytoplasm neoplasms |
| Zdroj: | Acta Pathologica Microbiologica Scandinavica Series A :Pathology. :393-396 |
| ISSN: | 0108-0164 |
| DOI: | 10.1111/j.1699-0463.1982.tb00112_90a.x |
| Popis: | The presence of carcino-embryonic antigen (CEA) was studied in 92 consecutive cases of gastric adenocarcinoma, using the two-layer conjugated immunoperoxidase technique. Three characteristic patterns of CEA localization were identified. Type I: Intracytoplasmatic granules covering the entire cytoplasm of the malignant cells. Type II. Linear or granular deposits along the glycocalyx or in the apical cytoplasm of the malignant cells. Type III: Tumour cells negative for CEA or only showing a very weak reaction in a few cells. These CEA patterns were significantly related to the histogenetic classification of gastric adenocarcinomas proposed by Mulligan & Rember. The majority of the "mucus cell carcinomas" showed the type I CEA pattern. "Intestinal cell carcinomas" predominantly showed the type II CEA pattern and the "pyloro-cardiac gland carcinomas" the type III CEA pattern. The significance of the CEA patterns in respect of the histogenetic classification is discussed. |
| Databáze: | OpenAIRE |
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