Gene repression in S. cerevisiae—looking beyond Sir-dependent gene silencing

Autor: Safia Mahabub Sauty, Krassimir Yankulov, Kholoud Shaban
Rok vydání: 2020
Předmět:
Zdroj: Current Genetics. 67:3-17
ISSN: 1432-0983
0172-8083
DOI: 10.1007/s00294-020-01114-7
Popis: Gene silencing by the SIR (Silent Information Region) family of proteins in S. cerevisiae has been extensively studied and has served as a founding paradigm for our general understanding of gene repression and its links to histone deacetylation and chromatin structure. In recent years, our understanding of other mechanisms of gene repression in S.cerevisiae was significantly advanced. In this review, we focus on such Sir-independent mechanisms of gene repression executed by various Histone Deacetylases (HDACs) and Histone Methyl Transferases (HMTs). We focus on the genes regulated by these enzymes and their known mechanisms of action. We describe the cooperation and redundancy between HDACs and HMTs, and their involvement in gene repression by non-coding RNAs or by their non-histone substrates. We also propose models of epigenetic transmission of the chromatin structures produced by these enzymes and discuss these in the context of gene repression phenomena in other organisms. These include the recycling of the epigenetic marks imposed by HMTs or the recycling of the complexes harboring HDACs.
Databáze: OpenAIRE
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