| Autor: |
Ming Yu WangChu, Bai Chuan Pan, Shih Hsi Chu, Zhi Hao Chen, Edward Chu |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Nucleosides and Nucleotides. 17:2367-2382 |
| ISSN: |
0732-8311 |
| DOI: |
10.1080/07328319808004324 |
| Popis: |
5-Halogeno-6-amino-2′-deoxyuridines were synthesized from 2′-deoxyuridine as potential thymidine phosphorylase (ThdPase) inhibitors. Among the compounds synthesized, 5-bromo-6-amino-2′-deoxyuridine (6) and 5-iodo-6-amino-2′-deoxyuridine (9) were found to inhibit ThdPase activity with IC50 values of 1.3 μM and 6.5 μM, respectively. In vitro cell culture studies showed that compound (6) can significantly enhance the cytotoxic effects of 5-fluoro-2′-deoxyuridine against a human colon cancer HCT-8 cell line. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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