Eosinophilic ulcer of the oral mucosa: another histological simulator of CD30+ lymphoproliferative disorders
| Autor: | J. Ferrando, Sonia Segura, L. Colomo, D. Romero, José M. Mascaró, Teresa Estrach |
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| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty education.field_of_study business.industry Population Lymphoproliferative disorders Eosinophilic ulcer of the oral mucosa Dermatology Riga–Fede disease medicine.disease medicine.anatomical_structure Eosinophilic granuloma Granuloma medicine Oral mucosa education business Histiocyte |
| Zdroj: | British Journal of Dermatology. 155:460-463 |
| ISSN: | 0007-0963 |
| DOI: | 10.1111/j.1365-2133.2006.07331.x |
| Popis: | Eosinophilic ulcer of the oral mucosa (EUOM), also known as traumatic ulcerative granuloma with stromal eosinophilia or Riga-Fede disease, is an uncommon benign self-limited lesion poorly described in the dermatological literature. It probably includes a spectrum of related disorders presenting as an ulcer with elevated indurated borders affecting the tongue, oral mucosa or lip. Histopathological findings are characteristic and consist of eosinophil-rich mixed infiltrates accompanied by a population of large mononuclear cells whose origins have been a matter of debate. Immunohistochemical studies of these cells have suggested a myofibroblastic or histiocytic origin. We present a 93-year-old woman with two episodes of self-healing ulcers on the upper lip and on the lingual mucosa, respectively. Histopathological findings on both biopsies were consistent with EUOM and showed the presence of large atypical CD30+ lymphocytes. Some recent reports have also shown positivity for the CD30 antigen, raising the possibility that a subset of EUOM could be included within the spectrum of CD30+ lymphoproliferative disorders. This finding most likely suggests that EUOM can represent another histological simulator of CD30+ lymphoproliferative disorders. |
| Databáze: | OpenAIRE |
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