| Popis: |
The continued development of NSOM is expanding its capabilities as an analytical tool and here we have examined only a few of those techniques currently in development. However, a general trend is clear; the means by which NSOM may be used to characterize molecular properties at the nanometric scale is rapidly diversifying, and is not merely limited to traditional fluorescence measurements. Whether through modification of the NSOM probe or the experimental approach, these new NSOM capabilities will undoubtedly find applications across disciplines. For the biological sciences in particular, NSOM seems poised to make a significant impact as we have tried to point out throughout this survey. Progress in this area has been slowed by problems associated with imaging soft and fragile samples. However, recent advances in tip and feedback designs are rapidly advancing the technique and it seems hard to imagine that this final hurdle will not be overcome before the publication of this edition. |
