Aseptic Peritonitis Revealed Through Recurrent Catheter Obstructions in Type 1 Diabetic Patients Treated with Continuous Peritoneal Insulin Infusion
| Autor: | Isabelle Raingeard, Eric Renard, Guy Costalat, Dominique Apostol, Françoise Boulet, Dominique Lauton, Jacques Bringer |
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| Rok vydání: | 2004 |
| Předmět: |
Advanced and Specialized Nursing
Pathology medicine.medical_specialty biology business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment medicine.disease Fibrin Macrophage chemotaxis Catheter Giant cell Fibrosis Diabetes mellitus Immunology Internal Medicine biology.protein Medicine Antibody business |
| Zdroj: | Diabetes Care. 27:276-277 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.27.1.276 |
| Popis: | Reiterated catheter obstructions thwart improved diabetes control with continuous peritoneal insulin infusion (CPII) from implantable pumps (1). Occlusions, from either fibrin clots or omental encapsulations, are promoted by CPII and diabetes duration and insulin instability (2,3). Pathological analysis of encapsulation tissues disclosed, among predominant collagen fibrosis, inflammatory reactions, including lymphocytes and amyloid-like deposits reacting to anti-insulin antibodies, surrounded by histiocytes or giant cells (2). However, catheter obstructions were not related to high plasma anti-insulin antibody levels (4,5). Enhanced migration toward insulin and the chemotactic peptide formyl-methionyl-leucyl-phenylalanine of monocyte-issued macrophages from three patients with previous catheter encapsulations suggested that higher macrophage chemotaxis might promote these events (5). We report two unique observations of … |
| Databáze: | OpenAIRE |
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