Baicalin Alleviates Nitroglycerin-induced Migraine in Rats via the Trigeminovascular System

Autor: Chun-Feng Zhang, Chun-Su Yuan, Wan-Li Hu, Wen-Juan Du, Cui-Lan Dong, Fei Li, Cheng-Long Cui, Jun Ji, Yu-Yao Sun, Ling Wang, Chong-Zhi Wang, Xiao-Fan Zhang, Wen-Jun Zhang, Xue Wang
Rok vydání: 2017
Předmět:
Zdroj: Phytotherapy Research. 31:899-905
ISSN: 0951-418X
DOI: 10.1002/ptr.5811
Popis: Migraine is a common neurological disorder with a serious impact on quality of life. The aim of this study was to explore the effect of baicalin on nitroglycerin-induced migraine rats. We carried out a behavioral research within 2 h post-nitroglycerin injection, and blood samples were drawn for measurements of nitric oxide (NO), calcitonin gene-related peptide, and endothelin (ET) levels. Immunohistochemistry was adopted to detect the activation of C-fos immunoreactive neurons in periaqueductal gray. The number, area size, and integrated optical density of C-fos positive cells were measured using Image-Pro Plus. As a result, baicalin administration (0.22 mm/kg) alleviated pain responses of migraine rats. It profoundly decreased NO and calcitonin gene-related peptide levels, increased ET levels, and rebuilt the NO/ET balance in migraine rats. Besides, baicalin pretreatment significantly reduced the number, the stained area size, and integrated optical density value of C-fos positive cells. In brief, this paper supports the possibility of baicalin as a potential migraine pharmacotherapy. Copyright © 2017 John Wiley & Sons, Ltd.
Databáze: OpenAIRE
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