N-alkylation of N1-mesitylenesulphonylputrescine with N-(4-bromobutyl)phthalimide: A Parallel Approach Using Multipin Solid-phase Synthesis

Autor:	S. Tomasi, M. Le Roch, J. Renault, J.C. Corbel, P. Uriac
Rok vydání:	2000
Předmět:	Pharmacology Phthalimide chemistry.chemical_compound Solid-phase synthesis Chemistry Pharmaceutical Science Organic chemistry Organic synthesis Alkylation Combinatorial chemistry
Zdroj:	Pharmacy and Pharmacology Communications. 6:155-159
ISSN:	1460-8081
DOI:	10.1211/146080800128735818
Popis:	Many problems are encountered in the synthesis of polyamines, natural compounds of biological interest. We describe here the rapid optimization of experimental conditions for the synthesis of orthogonally substituted triamines starting from simple building blocks-diamines and bromoalkylphthalimides. For this purpose we have adapted Bergeron's liquid-phase method (N-alkylation of sulphonamides) to solid-phase organic synthesis. The solid support was Multipin crowns enabling rapid optimization of the key-step-deprotonation of the sulphonamide. The combination of different building-blocks could lead to wide diversity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e92974e77c382a1818d38994d259ab14 https://doi.org/10.1211/146080800128735818 Zobrazit plný text záznamu Plný text