Serum prevalence of B cell stimulatory TLR ligands, elevated B cell TLR2 expression and regulatory B cell frequency precede the genesis of HIV-non-Hodgkin’s lymphoma (NHL) in ART treated HIV+ subjects (TUM7P.951)

Autor:	Basile Siewe, Joey Pham, Mardge Cohen, Nancy Hessol, Alexandra Levine, Otoniel Martinez-Maza, Alan Landay
Rok vydání:	2014
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 192:203.33-203.33
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.192.supp.203.33
Popis:	TLR2-signaling may contribute to B-cell activation during HIV infection leading to HIV-NHL genesis; a common malignancy in anti-retroviral therapy (ART) treated patients. TLR-signaling and anti-tumor immunity inhibitory regulatory B cells (Bregs) contribute to lymphomagenesis but their roles in HIV-NHL genesis remain unexplored. We investigated, if in HIV- donors, TLR-activated B cells mimic an activated/germinal center (GC)-like phenotype aberrantly expressed in B-cell lymphomas. Further, in HIV+ART subjects: (cases =
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e92206864a44a65e79bfe25ca8f7d26b https://doi.org/10.4049/jimmunol.192.supp.203.33 Zobrazit plný text záznamu