IOP lowering effect of low intensity ultrasound on experimental glaucoma model using microbeads in rats
| Autor: | N Lee, S Rho, Shin Goo Park, Nr Kim, C.Y. Kim, B Choi, C. Lee, Mj Choi |
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| Rok vydání: | 2012 |
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Alternative methods
medicine.medical_specialty Intraocular pressure genetic structures biology business.industry Untreated group Glaucoma General Medicine Repeatability medicine.disease biology.organism_classification eye diseases Ophthalmology Low intensity ultrasound Injection into anterior chamber Medicine Lius sense organs business |
| Zdroj: | Acta Ophthalmologica. 90 |
| ISSN: | 1755-375X |
| Popis: | Purpose To report the intraocular pressure (IOP) lowering effect of low intensity ultrasound (LIUS) on eyes of ocular hypertensive rats. Methods Continuous radiation of LIUS on ocular hypertensive eyes induced by unilateral microbeads injection was performed. A round plane ultrasound transducer operating at a frequency of 1MHz was utilized to deliver a sonication of 240mW/cm2 in acoustic intensity. LIUS was treated on both eyes of rats (n=5) simultaneously and the IOP measurements of treated group were compared with those of untreated group (n=5). Results The mean IOPs of LIUS-treated eyes and un-treated eyes were 9.4 ± 0.55 mmHg and 9.6 ± 0.55 mmHg, respectively at baseline. After an intracameral injection of microbeads, IOPs were reached to 18.6 ± 4.037 mmHg and 22.8 ± 3.493 mmHg (p=0.580) at 3 days after microbeads injection. Then the IOPs were decreased by 39.47 % and 9.68 % at 1 day after a single sonication. Conclusion These results showed that continuous low intensity ultrasound suppresses the IOP elevation in experimental glaucoma model using microbeads injection into anterior chamber. By the reason of its non-invasiveness and repeatability, LIUS could be an alternative method for glaucoma treatment in near future. |
| Databáze: | OpenAIRE |
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