Trends in dementia prevalence, incidence, and survival rate in a Japanese community
| Autor: | Daigo Yoshida, Masaharu Nagata, Toshiharu Ninomiya, Yutaka Kiyohara, Jun Hata, Takanari Kitazono, Shigenobu Kanba, Naoko Mukai, Toru Iwaki, Tomoyuki Ohara |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
business.industry Cross-sectional study Incidence (epidemiology) Hazard ratio medicine.disease 03 medical and health sciences 0302 clinical medicine Internal medicine Cohort Medicine Dementia 030212 general & internal medicine Neurology (clinical) Alzheimer's disease business Prospective cohort study Survival rate 030217 neurology & neurosurgery |
| Zdroj: | Neurology. 88:1925-1932 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | Objective:To investigate secular trends in the prevalence, incidence, and survival rate of dementia in a Japanese elderly population in a comprehensive manner.Methods:Five cross-sectional surveys of dementia were conducted among residents of a Japanese community, aged ≥65 years, in 1985, 1992, 1998, 2005, and 2012. We also established 2 cohorts consisting of the residents of this age group without dementia in 1988 (n = 803) and 2002 (n = 1,231), and each was followed for 10 years.Results:The age-standardized prevalence of all-cause dementia and Alzheimer disease (AD) increased with time (for all-cause dementia: 6.8% in 1985, 4.6% in 1992, 5.3% in 1998, 8.4% in 2005, and 11.3% in 2012, p for trend p for trend p for trend = 0.59). The age- and sex-adjusted incidence of all-cause dementia and AD, but not VaD, increased from the 1988 cohort to the 2002 cohort (for all-cause dementia: adjusted hazard ratio [aHR] 1.68, 95% confidence interval [CI] 1.38–2.06; for AD: aHR 2.07, 95% CI 1.59–2.70; for VaD: aHR 1.18, 95% CI 0.83–1.69). The 5-year survival rate of all-cause dementia and AD improved from the 1988 cohort to the 2002 cohort (for all-cause dementia: 47.3% to 65.2%; for AD: 50.7% to 75.1%; all p < 0.01).Conclusions:The increased incidence and improved survival rate of AD could have resulted in the steep increase in AD prevalence in the Japanese elderly. |
| Databáze: | OpenAIRE |
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