Effect of processing on metabolism of amgydalin from bitter almond in rat
| Autor: | Shixiang Wang, Xiaohui Zheng, Minfeng Fang, Qilin Wang, Zhiling Fu, Chao-ni Xiao |
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| Rok vydání: | 2010 |
| Předmět: |
Chromatography
Chemistry Amygdalin food and beverages Metabolism High-performance liquid chromatography Sprague dawley Metabolic pathway chemistry.chemical_compound stomatognathic system Complementary and alternative medicine Prunasin Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics psychological phenomena and processes |
| Zdroj: | China Journal of Chinese Materia Medica. |
| ISSN: | 1001-5302 |
| DOI: | 10.4268/cjcmm20102009 |
| Popis: | Objective To study the influence of processing on metabolism of the main component of bitter almond-amygdalin in rat. Method The blood was collected at different times after amygdalin given by injection and oral, bitter almond and its processed production given by oral respectively, and then detected by both HPLC and HPLC-MS(n) methods after extraction pretreatment. Result After injection, amygdalin was absorbed in prototype to blood rapidly, while the other three kinds of medicine given by oral were all not detected the prototype of amygdalin, but two metabolites were detected which were isomers of prunasin confirmed by mass spectrometry. The metabolic pathway of prunasin in processed bitter almond group was markedly different from the bitter almond group. Conclusion Processing has a significant effect on bitter almond metabolic processes in rats. |
| Databáze: | OpenAIRE |
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