| Autor: |
Dodge, R. C., Boerwinkle, E., Couper, D., Sun, W., Crosby, J. R., Gaubatz, J. W., Hoogeveen, R. C., Ballantyne, C. M., Virani, S. S., Jiang, J., Kathiresan, S. |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| DOI: |
10.17615/zt7k-cm75 |
| Popis: |
OBJECTIVE: To investigate the relationship between plasma levels of small dense low-density lipoprotein-cholesterol (sdLDL-C) and risk for incident coronary heart disease (CHD) in a prospective study among Atherosclerosis Risk in Communities (ARIC) study participants. APPROACH AND RESULTS: Plasma sdLDL-C was measured in 11 419 men and women of the biracial ARIC study using a newly developed homogeneous assay. A proportional hazards model was used to examine the relationship among sdLDL-C, vascular risk factors, and risk for CHD events (n=1158) for a period of ≈11 years. Plasma sdLDL-C levels were strongly correlated with an atherogenic lipid profile and were higher in patients with diabetes mellitus than non-diabetes mellitus (49.6 versus 42.3 mg/dL; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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