Onset and mortality of Parkinson’s disease in relation to type II diabetes

Autor: Gianni Pezzoli, Emanuele Cereda, Paolo Amami, Santo Colosimo, Michela Barichella, Giorgio Sacilotto, Anna Zecchinelli, Michela Zini, Valentina Ferri, Carlotta Bolliri, Daniela Calandrella, Maria Grazia Bonelli, Viviana Cereda, Elisa Reali, Serena Caronni, Erica Cassani, Margherita Canesi, Francesca del Sorbo, Paola Soliveri, Luigi Zecca, Catherine Klersy, Roberto Cilia, Ioannis U. Isaias
Rok vydání: 2022
Předmět:
Zdroj: Journal of Neurology. 270:1564-1572
ISSN: 1432-1459
0340-5354
Popis: Objectives There is growing evidence that Parkinson’s disease and diabetes are partially related diseases; however, the association between the two, and the impact of specific treatments, are still unclear. We evaluated the effect of T2D and antidiabetic treatment on age at PD onset and on all-cause mortality. Research design and methods The standardized rate of T2D was calculated for PD patients using the direct method and compared with subjects with essential tremor (ET) and the general Italian population. Age at onset and survival were also compared between patients without T2D (PD-noT2D), patients who developed T2D before PD onset (PD-preT2D) and patients who developed T2D after PD onset (PD-postT2D). Results We designed a retrospective and prospective study. The T2D standardized ratio of PD (N = 8380) and ET (N = 1032) patients was 3.8% and 6.1%, respectively, while in the Italian general population, the overall prevalence was 5.3%. In PD-preT2D patients, on antidiabetic treatment, the onset of PD was associated with a + 6.2 year delay (p p p = 0.54). Conclusions T2D, treated with any antidiabetic therapy before PD, is associated with a delay in its onset. Duration of diabetes increases mortality in PD-preT2D, but not in PD-postT2D. These findings prompt further studies on antidiabetic drugs as a potential disease-modifying therapy for PD.
Databáze: OpenAIRE
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