216 Endothelin-1 Levels in Preterm Newborns with Respiratory Distress Syndrome
| Autor: | Rita de Cássia dos Santos Silveira, Ana Claudia Weber Benjamin, Renato S. Procianoy |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Mechanical ventilation
medicine.medical_specialty Cord Respiratory distress business.industry Obstetrics medicine.medical_treatment Gestational age Venous blood Surfactant therapy Umbilical cord medicine.anatomical_structure Informed consent Pediatrics Perinatology and Child Health Medicine business |
| Zdroj: | Pediatric Research. 56:500-500 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-200409000-00239 |
| Popis: | Background: Exact role of endothelin-1 (ET-1) in respiratory distress syndrome (RDS) of the preterm infant is still unclear. Therefore, the aim was to assess umbilical cord and plasma levels of ET-1 in preterm newborns with RDS in comparison to control preterm infants. Methods: We studied preterm newborn infants with gestational age less than 34 weeks, and birthweight less than 2000 grams. Immediately after birth, a segment of umbilical cord was doubly clamped, and a blood sample was collected. Peripheral venous blood was collected 12 to 48 hours after birth. Both samples were utilized to determine ET-1 levels by enzyme-immunoassay. Patients were divided in RDS and control groups. Sample size was estimated to be 17 patients in each group for detection of a difference in ET-1 levels between both groups of 40%, with a significance of 5%, and a power of 80%. The study protocol was approved by the Ethics Committee at Hospital de Clinicas de Porto Alegre and informed consent was obtained from patients' parents or guardians.There were no venous punctures performed only for the study. This study had no funding sources of commercial nature and/or consulting or holding of significant equity in a company that could be affected by the results. Results: Forty newborn infants were included, 18 in RDS and 22 in control groups. Seventeen RDS patients received surfactant therapy in the first hours of life, twelve required mechanical ventilation, three developed bronchoplumonary displasia (BPD), and five died. None of the control infants received surfactant therapy, mechanical ventilation, developed BPD or died. Conclusions: 1.Umbilical cord ET-1 levels in both groups were similar.2.ET-1 levels in blood samples collected 12 to 48 hours after birth were significantly higher in RDS infants in comparison to control group.3.Those findings suggest ET-1 is involved in the pathogenesis of pulmonary vascular reactivity in preterm infants with RDS. |
| Databáze: | OpenAIRE |
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