Photodynamic therapy and nuclear imaging activities of SubPhthalocyanine integrated TiO2 nanoparticles
| Autor: | Ozge Er, Cigir Biray Avci, Cumhur Gündüz, Kasim Ocakoglu, Mine Ince, Fatma Aslıhan Sarı, Cansu Caliskan Kurt, Fatma Yurt, Hale Melis Soylu, Suleyman Gokhan Colak |
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| Rok vydání: | 2018 |
| Předmět: |
Chemistry
Nuclear imaging General Chemical Engineering medicine.medical_treatment Tio2 nanoparticles General Physics and Astronomy Photodynamic therapy 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease Colon tumors 01 natural sciences digestive system diseases In vitro 0104 chemical sciences Hepatocellular carcinoma medicine Cancer research Colorectal adenocarcinoma 0210 nano-technology Liver cancer |
| Zdroj: | Journal of Photochemistry and Photobiology A: Chemistry. 367:45-55 |
| ISSN: | 1010-6030 |
| Popis: | In this study, Subphthalocyanine (SubPc) and SubPc integrated TiO2 nanoparticles (SubPc- TiO2) were examined as theranostic agents. In vitro photodynamic therapy (PDT) efficiency of SubPc/SubPc-TiO2 and nuclear imaging potential of 131I labeled SubPc/TiO2-SubPc were determined on hepatocellular carcinoma (HepG2), colorectal adenocarcinoma (HT29) and human healthy lung (WI38) cell lines. As a result, 131I-SubPc and 131I-SubPc-TiO2 have been identified as a nuclear imaging agent for liver cancer. Additionally, 131I-SubPc-TiO2 has been found to be promising for imaging colon tumors. According to the in vitro photodynamic therapy studies, SubPc and SubPc-TiO2 were determined suitable PDT agents for liver and colon tumors. These results suggest that SubPc-TiO2 might be a theranostic agent with both PDT and nuclear imaging potential. |
| Databáze: | OpenAIRE |
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