Studies of the Toxicity of Hypaque-90 Per Cent, Following Rapid Intravenous Injection

Autor:	Richard L. Davis, John D. Palmer, Thomas A. Aaberg, Eugene F. Bernstein
Rok vydání:	1961
Předmět:	medicine.medical_specialty Aortography medicine.diagnostic_test Low toxicity business.industry Coronary arteriography Surgery Clinical Practice Anesthesia Toxicity Angiography medicine Radiology Nuclear Medicine and imaging Triiodobenzoate Selective angiocardiography business
Zdroj:	Radiology. 76:88-95
ISSN:	1527-1315 0033-8419
DOI:	10.1148/76.1.88
Popis:	Progress in angiography has been directly related to the availability of agents with a high degree of radiopacity and low toxicity. Recent advances in selective angiocardiography, coronary arteriography, and intravenous aortography depend upon the use of large doses of concentrated radiopaque materials. Several studies (6, 7) have indicated that agents of the triiodobenzoate group may be administered in very large doses intravenously without toxic effects. In these experiments, however, the drugs have been administered over a period of minutes, while in clinical practice they are commonly injected within a few seconds. This study is an evaluation of the acute physiologic and toxic effects of 3,5-diacetamido 2,4,6-triiodobenzoate (Hypaque4), one of the most commonly employed watersoluble iodinated angiographic media, following rapid intravenous injection. An experimental procedure has been devised which, as closely as possible, mimics the currently utilized method of intravenous aortography as practiced at...
Databáze:	OpenAIRE
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