Inhibition of human leukocyte elastase (HLE) by novel bicyclic β-lactams
| Autor: | Rebecca Williams, Robert A. Volkmann, Alice V. Bakker, Robin W. Spencer, W. Stephen Faraci, V. John Jasys, Michael S. Kellogg |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
biology Bicyclic molecule Stereochemistry Organic Chemistry Clinical Biochemistry Sulfenamide Pharmaceutical Science Biological activity Biochemistry Human Leukocyte Elastase chemistry.chemical_compound Enzyme chemistry Enzyme inhibitor Drug Discovery β lactams biology.protein Lactam Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:2271-2276 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)80938-0 |
| Popis: | Novel 3,2,0 bicyclic β-lactam sulfenamides and selected carbon isosteres are inhibitors of human leukocyte elastase. The comparative biological activity and hydrolytic stability of these compounds are described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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