| Autor: |
Qian Lv, Shengyao Yan, Tingting Bo, Zheng Wang, He Wang, Zilong Qiu, Yuanjing Feng, Qiming Lv, Xiaoyong Zhang, Fuqiang Xu, Wenwen Yu, Yilin Liu, Baofeng Yang, Xiaoyu Chen, Xiangyu Shen, Mingchao Yan, Yafeng Zhan |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Resolving trajectories of axonal pathways in the primate prefrontal cortex remains crucial to gain insights into higher-order processes of cognition and emotion, which requires a comprehensive map of axonal projections linking demarcated subdivisions of prefrontal cortex and the rest of brain. Here we report a mesoscale excitatory projectome issued from the ventrolateral prefrontal cortex (vlPFC) to the entire macaque brain by using viral-based genetic axonal tracing in tandem with high-throughput serial two-photon tomography, which demonstrated prominent monosynaptic projections to other prefrontal areas, temporal, limbic and subcortical areas, relatively weak projections to parietal and insular cortices but no projections directly to the occipital lobe. In a common 3D space, we quantitatively validated an atlas of diffusion tractography-derived vlPFC connections with correlative enhanced green fluorescent protein-labelled axonal tracing, and observed generally good agreement except a major difference in the posterior projections of inferior fronto-occipital fasciculus. These findings raise an intriguing question as to how neural information passes along long-range association fiber bundles in macaque brains, and call for the caution of using diffusion tractography to map the wiring diagram of brain circuits. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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