The effects of progestin-only hormone treatment on QT interval in the adolescent female
| Autor: | Anne G. Farrell, Mark D. Ayers, Marcia L. Shew, Adam C. Kean, Patricia W. Brooks, Kelly A. Kean |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry medicine.drug_class Population Corrected qt 030204 cardiovascular system & hematology QT interval 03 medical and health sciences 0302 clinical medicine Blood pressure Increased risk 030225 pediatrics Internal medicine Pediatrics Perinatology and Child Health medicine Cardiology cardiovascular diseases Cardiology and Cardiovascular Medicine business Adverse effect education Progestin Hormone |
| Zdroj: | Progress in Pediatric Cardiology. 63:101341 |
| ISSN: | 1058-9813 |
| DOI: | 10.1016/j.ppedcard.2021.101341 |
| Popis: | Background Prolongation of the ECG derived QT interval predicts increased risk for sudden life-threatening arrhythmias. Many medicines are known to prolong the QT interval though current data demonstrate that progesterone given to premenopausal females 18 years old. The effects of this treatment on the corrected QT (QTc) in this population are unknown. Objective To describe the effect of exogenous progestin on the QTc in adolescent females. Methods In post-menarcheal females, Results There were 40 controls and 21 treated participants. The age range was 10 – 17 years. There were no differences between the groups with regard to race, height, weight, BMI, or blood pressure. In the controls, the mean QTc was 403 +/-19 milliseconds (ms) vs. 397 +/-15 ms in those treated (p=0.22). Those on progestin therapy had a shorter QTc by the same magnitude difference (six ms) as the hormonal naive group in the adult literature. Conclusions We report no adverse effects of progestin associated with QTc prolongation and a trend suggesting a decreased QTc in a population of post menarcheal-adolescent females. |
| Databáze: | OpenAIRE |
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