Salivary calprotectin levels are raised in patients with oral candidiasis or Sjögren’s syndrome but decreased by HIV infection
| Autor: | A. N. Denbury, Stephen Challacombe, S P Sweet |
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| Rok vydání: | 2001 |
| Předmět: |
Microbiology (medical)
Autoimmune disease Systemic disease Saliva business.industry Opportunistic infection Lymphocyte Immunology medicine.disease Microbiology stomatognathic diseases fluids and secretions medicine.anatomical_structure stomatognathic system Immunopathology medicine Calprotectin business General Dentistry Mycosis |
| Zdroj: | Oral Microbiology and Immunology. 16:119-123 |
| ISSN: | 0902-0055 |
| DOI: | 10.1034/j.1399-302x.2001.016002119.x |
| Popis: | Calprotectin levels were determined in whole saliva from patients predisposed to oral candidiasis due to HIV infection or Sjogren's syndrome and from patients with candidiasis associated with various oral disorders (e.g. lichen planus, oral ulceration). Mean calprotectin levels were higher in whole saliva (2 microgram/ml) than in parotid saliva (0.3 microgram/ml). Oral candidiasis was associated with raised whole saliva calprotectin levels in all groups studied. HIV infection was associated with lower levels of salivary calprotectin, in the presence of high or low salivary Candida counts, although CD4+ lymphocyte counts did not significantly correlate with calprotectin concentrations. Calprotectin levels were elevated in saliva from Sjogren's syndrome patients with oral candidiasis, consistent with mucosal transudation of calprotectin from inflamed mucosa and limited dilution due to decreased salivary flow rates. This study indicates that oral candidiasis is associated with raised calprotectin levels secondary to mucosal inflammation, but that diminution of this candidacidal factor due to HIV infection may be a predisposing factor in the aetiology of oral candidiasis. |
| Databáze: | OpenAIRE |
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