| Popis: |
serious adverse events were observed in 72.2 % and 42.3 % of the pts (drug related in 41.3 % and 9.5% of the pts), respectively (n = 496). Most common drug-related toxicities (incidence ≥3%) of any grade were fatigue (7.3 %), rash (5.4 %), pruritus (5.4 %), nausea (4.0 %), diarrhoea (4.0 %), stomatitis (4.0 %), mucosal inflammation (3.8 %), anemia (7.5 %), thrombocytopenia (4.0 %) and peripheral oedema (3.6 %). Median progression-free survival for total patient population was 4.4 mo, for the subgroup of 1 st |
