Non-Invasive Adaptive Control of the Feed Rate for High Cell Density CHO Cultures According to the pO2 Profile

Autor: Otto Doblhoff-Dier, D. Müller, Hermann Katinger
Rok vydání: 2008
Předmět:
Zdroj: Animal Cell Technology: Products from Cells, Cells as Products ISBN: 9780792360759
DOI: 10.1007/0-306-46875-1_39
Popis: For mass manufacture of animal cell culture derived biologicals continuous perfused high cell density or fed batch systems are favourable. We established a non-invasive adaptive control capable to optimize the feed rates of media in order to maximize the product concentration in the harvest without triggering nutrient limitations.
Databáze: OpenAIRE