| Autor: |
Wei-Chieh Mu, Danica Chen |
| Rok vydání: |
2020 |
| Předmět: |
|
| Popis: |
The free radical theory of aging was first proposed by Harman in the 1950s with the idea that oxidative damage accumulates with age and contributes to functional deteriorations during aging. Caloric restriction (CR) has been shown to be one of the most effective approaches to extend life span and health span. Recent advances in nutrient sensing have identified molecular regulators responsible for CR-mediated oxidative stress defense and underscore their importance in preserving stem cell maintenance and tissue integrity during aging. Deciphering molecular mechanisms of the oxidative stress response during CR will enhance our knowledge toward the biology of aging and provide insights into developing activators targeting the nutrient-sensing pathways to extend health span and life span. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
