Stem Cell Populations as Self-Renewing Many-Particle Systems
| Autor: | David J. Jörg, Yu Kitadate, Shosei Yoshida, Benjamin D. Simons |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Quantitative Biology::Tissues and Organs Self renewal Biology Condensed Matter Physics Quantitative Biology::Cell Behavior Active matter 03 medical and health sciences 0302 clinical medicine General Materials Science Stem cell Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Annual Review of Condensed Matter Physics. 12:135-153 |
| ISSN: | 1947-5462 1947-5454 |
| Popis: | This article reviews the physical principles of stem cell populations as active many-particle systems that are able to self-renew, control their density, and recover from depletion. We illustrate the dynamical and statistical hallmarks of homeostatic mechanisms, from stem cell density fluctuations and transient large-scale oscillation dynamics during recovery to the scaling behavior of clonal dynamics and front-like boundary propagation during regeneration. |
| Databáze: | OpenAIRE |
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