Facile access to γ-aminothiols from 1,3-thiazines via a microwave-assisted three-component reaction

Autor:	Rémi Legay, Mihaela Gulea, Vincent Reboul, Jean-François Lohier, Flavie Peudru
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Hydrolysis chemistry Component (thermodynamics) Organic Chemistry Drug Discovery Salt (chemistry) Biochemistry Combinatorial chemistry Microwave assisted
Zdroj:	Tetrahedron. 68:9016-9022
ISSN:	0040-4020
DOI:	10.1016/j.tet.2012.08.072
Popis:	A new efficient and general synthetic methodology to access γ-aminothiols was investigated and developed. 1,3-Thiazines were used as convenient precursors and were prepared by a fast microwave-assisted three-component reaction (3CR) of thioamides, aldehydes, and alkenes. The transformation of thiazines into aminothiols was achieved via a thiazinium salt hydrolysis, in three very facile steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e8bb9626f992cd0b758d0eb34b4490c7 https://doi.org/10.1016/j.tet.2012.08.072 Zobrazit plný text záznamu Full Text from ScienceDirect