| Autor: | Július Rajčáni, J. Matis, Andrea Vojvodová, Marcela Kúdelová |
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| Rok vydání: | 1997 |
| Předmět: |
Genetics
Sequence analysis viruses Nucleic acid sequence virus diseases General Medicine biochemical phenomena metabolism and nutrition Biology medicine.disease_cause Virology chemistry.chemical_compound Herpes simplex virus chemistry GenBank Vero cell medicine skin and connective tissue diseases Molecular Biology Peptide sequence Gene DNA |
| Zdroj: | Virus Genes. 15:155-159 |
| ISSN: | 0920-8569 |
| DOI: | 10.1023/a:1007915025086 |
| Popis: | The UL41 gene of the HSZP strain of herpes simplex virus type 1 (HSV-1) defective with respect to the early shutoff of host protein synthesis was sequenced and compared with the corresponding HSV-1 strain KOS and 17 gene sequences. In comparison with strain 17, nine mutations (base changes) were HSZP specific, five KOS specific and four were common for both strains. Nine mutations caused codon changes. Three of these mapped to the nonconserved regions and the others to the conserved regions of the functional map of UL4l gene. One KOS specific mutation mapped to the region responsible for the binding of the virion host shutoff (vhs) protein to the alpha-transinducing factor (VP16). The possible relationship between mutations and host shutoff function is discussed. The nucleotide sequence data of the UL41 gene of HSZP and KOS have been submitted to the Genbank nucleotide database and have been assigned the accesion numbers Z72337 and Z72338. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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