Chemical effects of nuclear transformations and possible formation of unknown derivatives with N-phenylquinazolinium structure

Autor:	Sergey N. Shurov, Roman V. Shchepin, N. E. Shchepina, Gennadii A. Badun, V. V. Avrorin
Rok vydání:	2019
Předmět:	Chemical effects Chemical substance 010405 organic chemistry Chemistry Computational chemistry Structure (category theory) Tritium Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences
Zdroj:	Radiochimica Acta. 108:105-111
ISSN:	2193-3405 0033-8230
Popis:	Quinazoline derivatives are well known to have a diverse array of therapeutic activities. Unfortunately, “classic” chemical synthesis does not provide an opportunity for the formation of N-phenyl quaternary 1,3-diazinium compounds. A devised nuclear-chemical method of synthesis based on chemical effects of nuclear transformations enables a new way of the direct nitrogen atom phenylation by the nucleogenic (generated by tritium β-decay) phenyl cations in 1,3-diazines, furnishing, based on our prediction, formation of previously unknown derivatives with N-phenyl quaternary quinazolinium scaffold.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e8b7895614977d72c521509dd4aa14c7 https://doi.org/10.1515/ract-2018-2970 Zobrazit plný text záznamu