Beh�et's disease in Japan and in Great Britain: a comparative study
| Autor: | HM Towler, B Shaer, Peter McCluskey, M. Muhaya, Susan Lightman, M Mochizuki, E Ikeda |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Erythema nodosum
Systemic disease Intraocular pressure medicine.medical_specialty genetic structures business.industry medicine.medical_treatment Behcet's disease Cataract surgery medicine.disease eye diseases Ophthalmology Internal medicine medicine Prednisolone Glaucoma surgery Immunology and Allergy business Uveitis medicine.drug |
| Zdroj: | Ocular Immunology and Inflammation. 8:141-148 |
| ISSN: | 0927-3948 |
| DOI: | 10.1076/0927-3948(200009)8:3;1-k;ft141 |
| Popis: | Behcet's disease (BD) is an important cause of visual morbidity throughout the world, but shows striking differences in racial predilection. Despite important advances in the therapeutic management of acute intraocular inflammation, the long-term impact of these new strategies on visual outcome of BD and their efficacy in different ethnic groups is unknown. A comparative study of patient characteristics, clinical ocular features and inflammatory score, and current therapy was undertaken on all patients fulfilling the International Study Group criteria for Behcet's disease and the Behcet's Disease Research Committee of Japan, who attended the Uveitis Clinics of Moorfields Eye Hospital (n=19) and Kurume University School of Medicine (KUS) (n=35) during a continuous consecutive four-week period. Japanese patients were significantly older (43.2+/-11.8 years) than the patients seen in London (35.4+/-8. 9 years). There was a predominance of male patients in both groups. All patients seen in KUS were Japanese, while the patients in London included 12 Caucasians, five Middle Eastern, one African, and one Asian. No significant differences were seen between the two populations in the duration of systemic disease or systems affected by the disease, such as mouth ulcers, genital ulcers, skin lesions including erythema nodosum, or arthritis. The duration of ocular disease was similar in both centres: around seven years. There was, however, a significant difference in the number of eyes with active anterior uveitis (59.7% KUS vs 18.4% London (chi-square: 5.4; p=0.006)) and/or posterior uveitis (31.3% KUS vs 18.4% London (chi-square: 5.42; p |
| Databáze: | OpenAIRE |
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