Serrated polyposis syndrome and the role of serrated polyps in colorectal cancer development
| Autor: | Yark Hazewinkel, Karam S. Boparai, Evelien Dekker |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Cpg island methylation
Oncology medicine.medical_specialty business.industry Colorectal cancer Gastroenterology medicine.disease medicine.disease_cause Serrated polyposis digestive system diseases Hyperplastic Polyp Internal medicine DNA methylation medicine Cancer research Clinical significance KRAS business neoplasms Sessile serrated adenoma |
| Zdroj: | Colorectal Cancer. 1:37-47 |
| ISSN: | 1758-1958 1758-194X |
| DOI: | 10.2217/crc.11.8 |
| Popis: | SUMMARY Serrated polyposis syndrome is characterized by the presence of multiple colorectal serrated polyps and is associated with an increased colorectal cancer risk. The mixture of distinct precursor lesion types and malignancies in serrated polyposis syndrome provides a unique model to study the recently proposed serrated neoplasia pathway. This pathway involves the progression of serrated polyps, that is, hyperplastic polyps, sessile serrated adenoma/polyps and/or traditional serrated adenomas, to colorectal cancer. The early genetic events of this route, as currently identified, are BRAF or KRAS mutations and an enhanced CPG island methylation status of multiple genes. There is evidence to suggest that a proportion of sporadic colorectal cancers originate from serrated polyps, which encompass molecular sequences of events such as hypermethylation of different genes and BRAF mutations. This review discusses the characteristics and clinical relevance of serrated polyps and provides an overview of the clinical aspects and treatment of serrated polyposis syndrome. |
| Databáze: | OpenAIRE |
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