Optical resolution of hexamethylbiphenol by cholesterol esterase and porcine pancreas lipase
| Autor: | Yoshitaka Kobayashi, Tetsuo Takemura, Jun Satoh, Go Emoto, Chihiro Yaginuma, C. Akira Horiuchi, Takamitsu Utsukihara, Yuta Takahashi |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
chemistry.chemical_classification
biology Stereochemistry Process Chemistry and Technology Absolute configuration Triacylglycerol lipase Bioengineering Biochemistry Catalysis Hydrolysis Enzyme medicine.anatomical_structure chemistry Sterol esterase biology.protein medicine Lipase Enantiomer Pancreas |
| Zdroj: | Journal of Molecular Catalysis B: Enzymatic. 55:104-109 |
| ISSN: | 1381-1177 |
| DOI: | 10.1016/j.molcatb.2008.02.007 |
| Popis: | Both enantiomers of 2,2′-dihydroxy-4,4′,5,5′,6,6′-hexamethybiphenyl (2), a potentially useful chiral synthon, were obtained with >99% ee in high enantioselectivity by cholesterol esterase or porcine pancreas lipase (PPL)-mediated hydrolysis of the corresponding (±)-dipentanoate or (±)-dihexanoate, respectively. Absolute configuration of (S)-3-bromo-2,6′-dimethoxy-4,5,6,2′,3′,4′-hexamethyl-biphenyl (2h) was determined by X-ray analysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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