REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers

Autor: Roy N. Alcalay, Nir Giladi, Laurie J. Ozelius, Roberto A. Ortega, Brooke Johannes, Marta San Luciano, Helen Mejia-Santana, Kira Yasinovsky, Cuiling Wang, Susan Bressman, Karen Marder, Avi Orr-Utreger, Anat Mirelman, Lorraine N. Clark, Amanda Glickman, Nancy Doan, Rachel Saunders-Pullman, Deborah Raymond
Rok vydání: 2015
Předmět:
Zdroj: Movement Disorders. 30:1834-1839
ISSN: 0885-3185
Popis: Background Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established. Methods One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire. Results Cut scores were met by 30.6% idiopathic PD, 19.7% LRRK2-PD, 6% nonmanifesting carriers, 20.4% related noncarriers, and 15% controls. The likelihood of abnormal scores was decreased in LRRK2-PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P < 0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2-PD versus 14 of 41 idiopathic PD (P < 0.05). Conclusions A lower frequency of abnormal questionnaire scores is seen in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD. © 2015 International Parkinson and Movement Disorder Society
Databáze: OpenAIRE
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