Selective damage of coloration centers inhomogeneously distributed in skin tissue under nanosecond near-IR laser pulses

Autor: Vladimir M. Chernyak, Dmitrii M. Kulakov, Ludmila V. Chernyshova
Rok vydání: 2005
Předmět:
Zdroj: SPIE Proceedings.
ISSN: 0277-786X
DOI: 10.1117/12.633108
Popis: The results are presented on the study of the damage of melanin granules contained in ex-vivo animal skin specimens under a series of single Nd:glass laser pulses of nanosecond duration, with intensity I ~ 108 W/cm2. The mechanism responsible for tissue damage at the given conditions is shown to be a selective photodisruption occurring due to preferential energy absorption by endogenic skin pigment. For such a complicated multicomponent structure as biotissue comprising substructures inhomogeneously distributed in the bulk of it and differing in physical and chemical properties, such a parameter as volume energy density becomes a decisive one for tissue damage. When its magnitude reaches the damage threshold value within the absorption loci it breaks whereas the surrounding tissue remains undisturbed.
Databáze: OpenAIRE