An efficient 1,2,4-triazine-based route to the louisianin alkaloids

Autor:	Pierre Wasnaire, Richard J. K. Taylor, Nicola Catozzi
Rok vydání:	2008
Předmět:	chemistry.chemical_compound Chemistry Yield (chemistry) Organic Chemistry Drug Discovery Pyridine Louisianin C Ring (chemistry) Biochemistry Combinatorial chemistry Triazine
Zdroj:	Tetrahedron Letters. 49:2865-2868
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2008.03.026
Popis:	A new, short and efficient route to louisianins C and D is described in which the pyridine ring is constructed from a disubstituted 1,2,4-triazine by an inverse-electron-demand Diels–Alder/retro-Diels–Alder/aromatisation cascade sequence. This eight-step route produces louisianin C in 16% overall yield from the commercially available 5-chloropent-1-yne.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e8975266f3febf514479076a8a189c90 https://doi.org/10.1016/j.tetlet.2008.03.026 Zobrazit plný text záznamu Full Text from ScienceDirect