Persistent and resurgent Na+ currents in vestibular calyx afferents

Autor:	Katherine J. Rennie, Frances L. Meredith
Rok vydání:	2020
Předmět:	Vestibular system Physiology General Neuroscience Sodium channel Afferent Neurons Na current Calyx chemistry.chemical_compound Crista chemistry otorhinolaryngologic diseases Tetrodotoxin Action potential firing Neuroscience
Zdroj:	Journal of Neurophysiology. 124:510-524
ISSN:	1522-1598 0022-3077
DOI:	10.1152/jn.00124.2020
Popis:	Action potential firing patterns differ between groups of afferent neurons innervating vestibular epithelia. We investigated the biophysical properties of Na+ currents in specialized vestibular calyx afferent terminals during postnatal development. Mature calyces express Na+ currents with transient, persistent, and resurgent components. Nav1.6 channels contribute to resurgent Na+ currents and may enhance firing in peripheral calyx afferents. Understanding Na+ channels that contribute to vestibular nerve responses has implications for developing new treatments for vestibular dysfunction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e893e8286334b94302838a91d20ad6b9 https://doi.org/10.1152/jn.00124.2020 Zobrazit plný text záznamu