Early intraneuronal Aβ deposition in the hippocampus of APP transgenic mice
| Autor: | Feng Shiun Shie, Lee-Way Jin, Renée C. LeBoeur |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Genetically modified mouse
medicine.medical_specialty General Neuroscience Subiculum Hippocampus Biology Hippocampal formation medicine.disease nervous system diseases Pathogenesis Endocrinology Internal medicine mental disorders medicine Amyloid precursor protein biology.protein Extracellular Alzheimer's disease |
| Zdroj: | NeuroReport. 14:123-129 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200301200-00023 |
| Popis: | Increasing evidence suggests that intraneuronal amyloid-beta (Abeta) accumulation may be an early event in Alzheimer's disease (AD) pathogenesis. However direct in vivo evidence regarding initial Abeta seeding is missing. Using an APP transgenic mouse model, our sensitive immunocytochemical procedures revealed a novel intraneuronal Abeta deposition in the somas of hippocampal CA1/subiculum neurons far in advance of the occurrence of extracellular Abetaplaques. These deposits increased exponentially with age and were elevated approximately 4-fold (p < 0.001) by high fat/high cholesterol diet. Abeta40 and Abeta42 were the major constituents of these deposits and were co-localized with lysosomal markers. Our results are consistent with the notion that the earliest Abeta deposition occurs intraneuronally, prior to extracellular amyloid plaque formation. |
| Databáze: | OpenAIRE |
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