Reproducibility of circumpapillary retinal nerve fiber layer measurements using handheld optical coherence tomography in sedated children
| Autor: | Natalie C. Glaug, Joel S. Schuman, Avital Cnaan, Hiroshi Ishikawa, Robert A. Avery, Chieh-Li Chen, Roger J. Packer |
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| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Reproducibility genetic structures medicine.diagnostic_test Intraclass correlation business.industry Coefficient of variation Nerve fiber layer Magnetic resonance imaging eye diseases Ophthalmology medicine.anatomical_structure Optical coherence tomography Pediatrics Perinatology and Child Health Cohort medicine Optic nerve sense organs business |
| Zdroj: | Journal of American Association for Pediatric Ophthalmology and Strabismus. 18:e12 |
| ISSN: | 1091-8531 |
| DOI: | 10.1016/j.jaapos.2014.07.038 |
| Popis: | PURPOSE: To determine the intraand intervisit reproducibility of circumpapillary retinal nerve fiber layer (RNFL) measures using handheld optical coherence tomography (OCT) in sedated children. DESIGN: Prospective cross-sectional and longitudinal study. METHODS: Children undergoing sedation for a clinically indicated magnetic resonance imaging for an optic pathway glioma and/or neurofibromatosis type 1 (NF1) had multiple 6 3 6 mm volumes (isotropic 300 3 300 or nonisotropic 1000 3 100 samplings) acquired over the optic nerve. Children with 2 handheld OCT sessions within 6 months were included in the intervisit cohort. The intraand intervisit coefficient of variation (CV) and intraclass correlation coefficient (ICC) were calculated for the average and anatomic quadrant circumpapillary RNFL thickness. RESULTS: Fifty-nine subjects (mean age 5.1 years, range 0.8–13.0 years) comprised the intravisit cohort and 29 subjects (mean age 5.7 years, range 1.8–12.7 years) contributed to the intervisit cohort. Forty-nine subjects had an optic pathway glioma and 10 subjects hadNF1 without an optic pathway glioma.TheCVwas comparable regardless of imaging with an isotropic and nonisotropic volume in both the intraand intervisit cohorts. The average circumpapillary RNFL demonstrated the lowest CV and highest ICC compared to the quadrants. For the intervisit cohort, the average ICC was typically higher while the CV was typically lower, but not statistically different compared to the other quadrants. |
| Databáze: | OpenAIRE |
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