Antifertility and biocidal activities of organometallics of silicon, germanium, titanium and zirconium derived from 2-acetylthiophene thiosemicarbazone

Autor:	Kashmir Singh, Ran V. Singh, Suresh Mehta, Devendra Singh, Anita Kumari, I. J. Gupta
Rok vydání:	1993
Předmět:	chemistry.chemical_classification Zirconium chemistry.chemical_element General Chemistry Carbon-13 NMR Inorganic Chemistry chemistry.chemical_compound chemistry Thiol Proton NMR Organic chemistry Molecule Semicarbazone Antibacterial agent Organosilicon
Zdroj:	Applied Organometallic Chemistry. 7:289-292
ISSN:	1099-0739 0268-2605
Popis:	A comparative biochemical study of four Group IV element compounds with specific sulphur-containing organic substrates has been carried out and discussed. The structural characterizations of these organometallics, viz. Me2SiLCl, Me2SiL2, Me3SiL, Ph2SiLCl, Ph2SiL2, Ph3SiL, Ph3GeL, Cp2TiLCl, Cp2TiL2, Cp2ZrLCl and Cp2ZrL2 (where LH2-acetylthiophene thiosemicarbazone) had been deduced on the basis of various physico-chemical and instrumental techniques, viz., IR, UV, 1H NMR, 13C NMR AND 29SI NMR spectral studies. All the organometallics and the parent thiomine have been screened against a number of microbes and their sterilizing power in male mice tested. The results of these biocidal studies show that the organosilicon(IV) and organogermanium(IV) compounds are more active than the organotitanium(IV) and organozirconium(IV) derivatives. An attempt has also been made to correlate the structural aspects of the molecule with its biological activity.
Databáze:	OpenAIRE
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