Thermo- and pH-responsive gels for application in colon delivery systems

Autor:	Ryoichi Katakai, Takeshi Suwa, Masaharu Asano, Masaru Yoshida
Rok vydání:	1999
Předmět:	Ketoprofen Radiation Diffusion Polyelectrolyte chemistry.chemical_compound Methacrylic acid chemistry Drug delivery Polymer chemistry Copolymer medicine Swelling medicine.symptom Drug carrier medicine.drug
Zdroj:	Radiation Physics and Chemistry. 55:677-680
ISSN:	0969-806X
DOI:	10.1016/s0969-806x(99)00210-8
Popis:	Swelling-controlled drug delivery copolymer gels were synthesized by introducing thermo- and pH-responsive methacryloyl-glycine (MA-Gly) of pH-responsive methacrylic acid (MA-Ac) into thermo-responsive acryloyl- l -proline ethyl ester (A-ProOEt). The threshold of swelling for copolymer gels consisting of A-ProOEt/MA-Gly and A-ProOEt/MA-Ac with a composition of 40/60 mol% was found to be pH 3.0 and pH 5.5, respectively, in buffer solutions at 37°C. The diffusion characteristics of 2-(3-benzoylphenyl)propionic acid (ketoprofen) from such copolymer gels were evaluated in buffer solutions at pHs more than 5.5, and it was found that A-ProOEt/MA-Gly gel possessed a Case II transport, while the A-ProOEt/MA-Ac gel exhibited a non-Fickian (or anomalous) diffusion behavior under the same conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e88bcc8420822f1b6325a8d8ed89ee96 https://doi.org/10.1016/s0969-806x(99)00210-8 Zobrazit plný text záznamu Full Text from ScienceDirect