The Effect of Ophiocephalus striatus sp. Extract on Nitric Oxide in Ischemic Stroke Model
| Autor: | Muhammad Ichwan, Iskandar Nasution, Syafruddin Ilyas, Hasan Sjahrir |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification 030102 biochemistry & molecular biology business.industry Angiogenesis General Medicine Pharmacology medicine.disease Amino acid Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry Ischemic stroke Medicine business Ligation Stroke 030217 neurology & neurosurgery Blood vessel Histological examination |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences. 9:68-74 |
| ISSN: | 1857-9655 |
| DOI: | 10.3889/oamjms.2021.6299 |
| Popis: | BACKGROUND: One of alternative medicine in stroke therapy is Ophiocephalus striatus sp. extract. The nutrients contained in the O. striatus sp. extract, namely amino acids, fatty acids, cuprum, and zinc, are useful for the process of angiogenesis in poststroke patients through increased endothelial nitric oxide synthase. AIM: We hypothesized that there was an effect of giving O. striatus sp. extract to cerebral angiogenesis process of Sprague Dawley rats ischemic stroke models through the level of NO. METHODS: This was evidenced by conducting experimental studies on rats ischemic stroke models which were divided into five groups, (a) K (−) group (no ligation, no treatment), (b) K (+) group (ligation, no treatment), (c) P1 group (ligation, 200 mg extract), (d) P2 group (ligation, 400 mg extract), and (e) P3 group (ligation, 800 mg extract). Then blood sample was taken on day 3 to assess levels of NO. RESULTS: There was increased level of NO in P1 (p = 0.001), P2 (p < 0.001), and P3 (p < 0.001) groups compared to K (+) group. The level of NO increases along with the increasing dose of O. striatus sp. extract. Histological examination revealed that there was formation of new blood vessel in the P1, P2, and P3 groups compared to K (+) group. CONCLUSION: Our study showed that O. striatus sp. extract improves cerebral angiogenesis in rat models of ischemic stroke. |
| Databáze: | OpenAIRE |
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