Spectroscopic Characterization Of Ozonides With Biological Activity

Autor:	Jesús Molerio, Irene Lezcano, Frank Hernández, Maritza F. Díaz
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Environmental Engineering food.ingredient Ozone Sunflower oil Fatty acid Hexane chemistry.chemical_compound food chemistry Proton NMR Environmental Chemistry Ozonide Organic chemistry Unsaturated fatty acid Antibacterial agent
Zdroj:	Ozone: Science & Engineering. 23:35-40
ISSN:	1547-6545 0191-9512
DOI:	10.1080/01919510108961986
Popis:	Ozonation reactions are very important in fatty acid chemistry since their ozonation products are involved in vital biological processes. When an unsaturated acid reacts with ozone in presence of an organic solvent, Criegee ozonides are produced according to the Criegee mechanism. These ozonides are relatively stable compounds, thus, in the organism they have biological effects at distant sites from the site they are formed. The antimicrobial activity of ozonized sunflower oil (O1eozonR) has been previously well documented. We have suggested that ozonides are involved in the antimicrobial effect of O1eozonR/. In this study we try to demonstrate this hypothesis. Ozonides were obtained by total reaction of ozone gas with a sample of methyl oleate in an organic solvent (hexane). Proton Nuclear Magnetic Resonance (H NMR) technique was used for identification of ozonides in ozonation products, whereas biological evaluation was done by determining Minimum Inhibitory Concentration (MIC), Minimum Bacteri...
Databáze:	OpenAIRE
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