Salivary CPLANE1 Levels as a Biomarker of Oral Squamous Cell Carcinoma

Autor:	Shuji Nomoto, Marico Takahashi, Kazuo Shimozato, Sei Ueda, Ichiro Oh-Iwa, Mitsuo Goto, Masahiko Imazawa, Toru Nagao, Kengo Hashimoto
Rok vydání:	2021
Předmět:	Oncology Cancer Research medicine.medical_specialty Saliva business.industry Microarray analysis techniques Cancer General Medicine medicine.disease stomatognathic diseases Internal medicine Gene expression Medicine Biomarker (medicine) In patient Basal cell business Survival rate
Zdroj:	Anticancer Research. 41:765-772
ISSN:	1791-7530 0250-7005
Popis:	Background/aim This study aimed to identify novel biomarkers for oral squamous cell carcinoma (OSCC) screening to improve the survival rate of patients with oral cancer. Materials and methods We investigated differential salivary gene expression in patients with OSCC, those with oral potentially malignant disorders (OPMDs), and healthy volunteers (HVs). CPLANE1 was selected for further investigation by microarray analysis. We used quantitative reverse transcription PCR (qRT-PCR) to determine CPLANE1 expression levels in the saliva. The expression of CPLANE1 in normal and oral cancer tissues was analyzed using the Gene Expression database of Normal and Tumor tissues. Results qRT-PCR analysis of saliva samples showed that CPLANE1 expression levels were significantly higher in OSCC patients than in HVs and OPMDs patients. Furthermore, we developed a screening test for OSCC using CPLANE1 and showed that it had good accuracy. Conclusion Salivary CPLANE1 could be a useful biomarker for OSCC screening and early detection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e872e9325c7477dc54ea109ad13bf26f https://doi.org/10.21873/anticanres.14828 Zobrazit plný text záznamu